Human X-linked inhibitor of apoptosis (XIAP) protein belongs to a family of apoptotic suppressor proteins that share a conserved motif, the baculovirus IAP repeat (BIR). The BIR motif is necessary for antiapoptotic function. XIAP plays a variety of other functional roles, such as also modulation of inflammatory signaling and immunity, mitogenic kinase signaling, cell proliferation, and copper homeostasis. XIAP acts as a caspase inhibitor by binding to the active site of caspase 3 and 7; it also inactivates caspase 9 by preventing it from forming active homodimers. Mutations in the XIAP gene are associated with X-linked lymphoproliferative syndrome. XIAP is also known as baculoviral IAP repeat-containing 4 (BIRC4), inhibitor of apoptosis protein 3 (IAP3), hIAP3, IAP-like protein, API3, ILP1, MIHA, and XLP2.
This product is an affinity-purified IgG antibody that recognizes human XIAP protein. The antibody was raised in rabbit using a synthetic peptide and can be used for Western blot (WB) detection of human XIAP protein.