TELO2 interacting protein 1 is a human homolog of the S. pombe Tel2 interacting protein 1, and is encoded by the TTI1 gene. It is part of the TTT complex that is required to stabilize the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. This complex regulates the response to DNA damage caused by radiation or DNA cross-linking agents. TTI1 also promotes the assembly, stabilizes, and maintains the activity of mammalian target of rapamycin complex 1 (mTORC1) and mTORC2; these complexes are responsible for regulating cell growth and survival in response to nutrient and hormonal signals. TTI1 is also known as Tel2 interacting protein 1 homolog (S. pombe); Tel2 interacting protein 1 homolog, KIAA0406, and smg-10 homolog, nonsense mediated mRNA decay factor (SMG10).
This product is an affinity-purified IgG antibody that recognizes human TTI1 protein. The antibody was raised in rabbit using a synthetic peptide and can be used for Western blot (WB) detection of human TTI1 protein.