Strand exchange protein 1 (SEP1) homolog was reported as a human gene responsive to stimulation by glial cell-derived neurotrophic factor (GDNF) in neuroblastoma cells. It was subsequently characterized as the human homolog to yeast XRN1 protein, a 5'-3' exoribonuclease. SEP1 is involved in mRNA degradation, and in a variety of other nuclear and cytoplasmic functions. It may also act as a tumor suppressor protein in osteogenic sarcoma (OGS). SEP1 is also known as XRN1 and 5'-3' exoribonuclease 1.
This product is an affinity-purified IgG antibody that recognizes human and mouse SEP1/XRN1 protein. The antibody was raised in rabbit using a synthetic peptide and can be used for Western blot (WB) detection, immunohistochemical (IHC) detection, or immunoprecipitation (IP) of human and mouse SEP1/XRN1 protein.