Retinoic acid-inducible gene I protein (RIG-I) is double-stranded (ds) RNA helicase that is encoded by the DDX58 gene in humans. RIG-I is a member of the DEAD box protein family, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD). In addition to the RNA helicase domain, RIG-I contains a caspase recruitment domain. RIG-I binds to 5'-triphosphorylated single-stranded (ss) RNA and short dsRNA (<1 kb). It is involved in recognition of viral dsRNA and regulation of the immune response to viral infection. RIG-I has also been suggested to play roles in granulocyte production and differentiation, bacterial phagocytosis, and regulation of cell migration.
This product is an affinity-purified IgG antibody that recognizes human RIG-I protein. The antibody was raised in rabbit using a synthetic peptide and can be used for Western blot (WB) or immunocytochemistry detection of human RIG-I protein.