Podocin is a component of the slit diaphragm of podocytes, cells that are located in the Bowman's capsule in the kidneys. In humans, it is encoded by the NPHS2 gene. In the glomerulus, blood is filtered through the slit diaphragms before passing into nephrons. Podocin is one of several proteins that control glomerular permeability. It acts as a linker between the plasma membrane and the cytoskeleton. Mutations in the NPHS2 gene cause autosomal recessive steroid-resistant nephrotic syndrome (SRNS), a disease that rapidly progresses to end-stage renal disease (ESRD). Podocin has also been implicated in the development of other nephropathies, such as focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD). Podocin is also known as nephrosis 2, idiopathic, steroid-resistant (podocin); PDCN, and SRN1.
This product is an affinity-purified IgG antibody that recognizes human podocin protein. The antibody was raised in rabbit using a synthetic peptide and can be used for Western blot (WB) detection, immunohistochemical (IHC) detection, or immunoprecipitation (IP) of human podocin protein.