Nephrin is a member of the immunoglobulin family of cell adhesion molecules that is required for the proper functioning of the glomerular filtration barrier in the kidney. The glomerular filtration barrier consists of fenestrated endothelial cells, the glomerular basement membrane, and specialized epithelial cells known as podocytes. Nephrin is found at the slit diaphragm of glomerular podocytes. The slit diaphragm functions as an ultrafilter to exclude albumin and other plasma macromolecules during the formation of urine. Mutations in the nephrin gene result in a disease known as Finnish-type congenital nephrosis 1, characterized by severe proteinuria (leakage of large amounts of protein into the urine). Nephrin is also known as nephrosis 1, congenital, Finnish type; CNF, NPHN, NPHS1, and renal glomerulus-specific cell adhesion receptor.
These products are affinity-purified IgG antibodies that recognizes human nephrin protein. The antibody was raised in rabbit using recombinant protein or a synthetic peptide, and can be used for Western blot (WB) detection, immunohistochemical (IHC) detection, or immunoprecipitation (IP) of human nephrin protein.