Langerhans cells (LC) are dendritic or antigen-presenting cells in the skin and mucous membranes, and contain large structures called Birbeck granules. They are also found in lymph nodes. They express immune response gene-associated antigens on their cell membranes. Langerhans cells in tissue actively capture, uptake, and process antigens. In secondary lymphoid tissue, LCs lose these properties while gaining the ability to interact with naive T-cells. The disease Langerhans cell histiocytosis (LCH) is caused by excess production of LCs. Langerhans cells are also implicated as early targets in HIV infection.
This product is an affinity-purified IgG antibody that recognizes human LCs. It reacts mainly with a protein found in Birbeck granules. The antibody was raised in mouse and can be used for immunohistochemical (IHC) detection of LCs.