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Cell Biology & Epigenetics


Products >  Cell_Biology_and_Epigenetics >  Miscellaneous >  Primary_Antibodies_A-K >  c-MPL

c-MPL Detection

The human c-MPL oncogene was identified as the human homolog of the murine myeloproliferative leukemia (MPL) virus oncogene, v-MPL. c-MPL encodes a protein with homology to members of the hematopoietic receptor superfamily. It is also known as MPLV, TPOR, CD110, and THCYT2. The protein thrombopoietin, a major regulator of megakaryocytopoiesis and platelet formation, was subsequently identified as the ligand for c-MPL. The protein encoded by the c-MPL gene (CD110) possesses two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. This protein exists as two alternatively spliced isoforms: c-MPL-P (wild type) and c-MPL-K (truncated). Antisense oligodeoxynucleotides of c-MPL have been shown to inhibit megakaryocyte colony formation. CD110-deficient mice are severely thrombocytopenic, suggesting an important role for CD110 in megakaryocyte and platelet formation.

Antibodies for c-MPL Detection

The c-MPL-P products are affinity-purified IgG antibodies that recognize human c-MPL-P protein. The antibody was raised in rabbit using a synthetic peptide and can be used for Western blot (WB) detection of human c-MPL-P protein.

The c-MPL/TPOR products are affinity-purified IgG antibodies (Cat. # 10401) and biotinylated antibodies (Cat. # 10403) that recognize mouse TPOR. The antibodies were raised in rat using a recombinant protein and can be used for Western blot (WB) detection, immunoprecipitation (IP), or flow cytometry (FCM) detection of mouse TPOR protein.

 
 
Products
Cat. # Product Contents Size Price Units Select
18505A Anti-Human c-MPL-P (M617) Rabbit IgG Affinity Purify 25 ug $125.00
18505B Anti-Human c-MPL-P (M617) Rabbit IgG Affinity Purify 100 ug $545.00
10401B Anti-Mouse c-MPL/TPOR (AMM2) Rat IgG MoAb 100 ug $545.00
10403A Anti-Mouse c-MPL/TPOR (AMM2) Rat IgG MoAb Biotin 5 ug $125.00
10403B Anti-Mouse c-MPL/TPOR (AMM2) Rat IgG MoAb Biotin 50 ug $545.00
 

 

 
 

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