The human c-MPL oncogene was identified as the human homolog of the murine myeloproliferative leukemia (MPL) virus oncogene, v-MPL. c-MPL encodes a protein with homology to members of the hematopoietic receptor superfamily. It is also known as MPLV, TPOR, CD110, and THCYT2. The protein thrombopoietin, a major regulator of megakaryocytopoiesis and platelet formation, was subsequently identified as the ligand for c-MPL. The protein encoded by the c-MPL gene (CD110) possesses two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. This protein exists as two alternatively spliced isoforms: c-MPL-P (wild type) and c-MPL-K (truncated). Antisense oligodeoxynucleotides of c-MPL have been shown to inhibit megakaryocyte colony formation. CD110-deficient mice are severely thrombocytopenic, suggesting an important role for CD110 in megakaryocyte and platelet formation.
Antibodies for c-MPL Detection
The c-MPL-P products are affinity-purified IgG antibodies that recognize human c-MPL-P protein. The antibody was raised in rabbit using a synthetic peptide and can be used for Western blot (WB) detection of human c-MPL-P protein.
The c-MPL/TPOR products are affinity-purified IgG antibodies (Cat. # 10401) and biotinylated antibodies (Cat. # 10403) that recognize mouse TPOR. The antibodies were raised in rat using a recombinant protein and can be used for Western blot (WB) detection, immunoprecipitation (IP), or flow cytometry (FCM) detection of mouse TPOR protein.