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Cell Biology & Epigenetics


Products >  Cell_Biology_and_Epigenetics >  Miscellaneous >  Primary_Antibodies_A-K >  c-MPL

c-MPL Detection

The human c-MPL oncogene was identified as the human homolog of the murine myeloproliferative leukemia (MPL) virus oncogene, v-MPL. c-MPL encodes a protein with homology to members of the hematopoietic receptor superfamily. It is also known as MPLV, TPOR, CD110, and THCYT2. The protein thrombopoietin, a major regulator of megakaryocytopoiesis and platelet formation, was subsequently identified as the ligand for c-MPL. The protein encoded by the c-MPL gene (CD110) possesses two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. This protein exists as two alternatively spliced isoforms: c-MPL-P (wild type) and c-MPL-K (truncated). Antisense oligodeoxynucleotides of c-MPL have been shown to inhibit megakaryocyte colony formation. CD110-deficient mice are severely thrombocytopenic, suggesting an important role for CD110 in megakaryocyte and platelet formation.

Antibodies for c-MPL Detection

The c-MPL-P products are affinity-purified IgG antibodies that recognize human c-MPL-P protein. The antibody was raised in rabbit using a synthetic peptide and can be used for Western blot (WB) detection of human c-MPL-P protein.

The c-MPL/TPOR products are affinity-purified IgG antibodies (Cat. # 10401) and biotinylated antibodies (Cat. # 10403) that recognize mouse TPOR. The antibodies were raised in rat using a recombinant protein and can be used for Western blot (WB) detection, immunoprecipitation (IP), or flow cytometry (FCM) detection of mouse TPOR protein.

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Features

Antigen
Cat. #
Application
Species
(Clone) and Source
 
Cross‑Reactivity
 
c‑MPL‑P (C‑terminus)18505A, BWBHuman

(M617)
Rabbit IgG

Cross‑reacts with UT‑7/
thrombopoietin

c‑MPL/TPOR (extracellular domain)10401A, BWB
IP
FC
NT
Mouse

(AMM2)
Rat IgG1 MoAb

n/a

c‑MPL/TPOR (extracellular domain)10403A, BWB
IP
FCM
NT
Mouse

(AMM2)
Rat IgG1 MoAb Biotin

n/a

Additional Information

Please see a product's User Manual and Data Sheet for information about storage conditions, product components, and technical specifications. Please see the User Manual to determine kit components. User Manuals and Data Sheets are located under the Documents tab.


 
 
Products
Cat. # Product Contents Size Price Units Select
18505A Anti-Human c-MPL-P (M617) Rabbit IgG Affinity Purify 25 ug $113.00
18505B Anti-Human c-MPL-P (M617) Rabbit IgG Affinity Purify 100 ug $499.00
10401A Anti-Mouse c-MPL/TPOR (AMM2) Rat IgG MoAb 10 ug $113.00
10401B Anti-Mouse c-MPL/TPOR (AMM2) Rat IgG MoAb 100 ug $499.00
10403A Anti-Mouse c-MPL/TPOR (AMM2) Rat IgG MoAb Biotin 5 ug $113.00
10403B Anti-Mouse c-MPL/TPOR (AMM2) Rat IgG MoAb Biotin 50 ug $499.00
 

 

 
 

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