Gastrin is a peptide hormone that stimulates secretion of gastric acid by the parietal cells of the stomach. Gastrin binds to a G-protein coupled receptor encoded by the CCKBR gene that also binds cholecystokinin (CCK), a brain regulatory peptide. The receptor is therefore known as the gastrin/cholecystokinin type B receptor. It is also known as cholecystokinin B receptor, cholecystokinin-2 receptor, CCK-B, CCKB-R, CCKRB, CCK2R, and GASR. The gastrin/cholecystokinin receptor is expressed mostly in central nervous system and the gastrointestinal tract. A misspliced transcript variant of the CCKBR gene that includes an intron has been associated with colorectal and pancreatic tumors.
This product is an affinity-purified IgG antibody that recognizes human gastrin receptor protein. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human gastrin receptor protein.