Anti-Human ERA (E. coli Ras-like protein) Rabbit IgG Antibody
Escherichia coli Ras-like protein (ERA) is a member of a conserved family of GTP-binding proteins that are required for proliferation. ERA was originally reported as a bacterial homolog of eukaryotic Ras proteins. Howber, However, DNA database searches and cDNA cloning studies have shown the existence of an ERA homolog in higher eukaryotes, including human, mouse, Drosophila, Caenorhabditis elegans, and Antirrhinum majus.
The biological function of eukaryotic ERA-like proteins is not known. The human ERA homolog has been cloned, and consists of a typical GTPase/GTP-binding domain, and a putative K homology (KH) RNA-binding domain. Studies indicate that the human ERA homolog regulates G1 phase progression via an unknown molecular mechanism that involves RNA recognition by ERA. It is also known as Era G-protein-like 1 (E. coli), Era (E. coli G-protein homolog)-like 1, conserved ERA-like GTPase, ERA-like protein 1, GTPase Era mitochondrial, ERAL1, ERA, ERA-W, HERA-A, HERA-B, H-ERA, and CEGA.
This product is an affinity-purified IgG antibody that recognizes human ERA homolog protein. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human ERA homolog protein.