Anaplastic lymphoma kinase (ALK) is a receptor type tyrosine kinase that belongs to the insulin receptor superfamily. It is also known as anaplastic lymphoma receptor tyrosine kinase, Tcrz, CD246, and NBLST3. ALK is expressed in the central and peripheral nervous system at late embryonic stage, and plays an important role in brain development. The ALK gene is rearranged, mutated, or amplified in various tumors, including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. This monoclonal antibody (clone mAb16-39) elicits tyrosine phosphorylation of ALK in human neuroblastoma (SK-N-SH) cells. It also induces further phosphorylation of signal transfer molecules like insulin receptor substrate-1 (IRD-1).
This product is an affinity-purified IgG antibody that recognizes mouse ALK protein. The antibody was raised in rat using a recombinant protein, and can be used for Western blot (WB) detection or immunoprecipitation (IP) of mouse ALK protein.