Rab27 is a member of the Rab subfamily of Ras GTPase proteins. Rab27 protein is membrane-bound and is post-translationally modified by the addition of geranylgeranyl groups on two C-terminal cysteines. Two isoforms of Rab27 are known, encoded by the RAB27A and RAB27B genes. Rab27A and Rab27B were found to control different steps of the exosome secretion pathway. Rab27 proteins are involved in melanosome transport in melanocytes and in killing activity in cytotoxic T lymphocytes. In addition, they have been suggested to play roles in protein transport and small GTPase-mediated signal transduction. Mutations in the RAB27A gene are associated with Griscelli syndrome type 2, a disease characterized by hypopigmentation and immunodeficiency. Rab27A is also known as RAB27A, member RAS oncogene family; GTP-binding protein Ram, RAB27, GS2, RAM, and HsT18676. Rab27B is also known as RAB27B, member RAS oncogene family; and C25KG2.
These products are affinity-purified IgG antibodies that recognize human, mouse, and rat Rab27A or Rab27B proteins. The antibodies were raised in rabbit using recombinant Rab27B protein and can be used for Western blot (WB) detection of Rab27A or Rab27B proteins.