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Cell Biology & Epigenetics


Products >  Cell_Biology_and_Epigenetics >  Metabolic_Diseases >  Adiponectin_Receptors

Adiponectin Receptor Detection

Human adiponectin is a protein hormone secreted by adipocytes that is involved in several metabolic functions, including the regulation of glucose levels and fatty acid metabolism. Two receptors for adiponectin have been identified that share homology with the G protein-coupled receptors (GPCRs): adiponectin receptor 1 (ADIPOR1) and adiponectin receptor 2 (ADIPOR2). Similar to GPCRs, ADIPOR1 and ADIPOR2 possess seven transmembrane domains. However, neither ADIPOR1 nor ADIPOR2 have been reported to associate with G proteins.

Binding of adiponectin to ADIPOR1 results in activation of an AMP-dependent kinase (AMPK) signaling pathway that regulates fatty acid oxidation and insulin sensitivity. ADIPOR1 is also known as progestin and adipoQ receptor family member I (PAQR1), CGI45, ACDCR1, and TESBP1A.

Binding of adiponectin to ADIPOR2 mediates increased AMP-activated protein kinase (AMPK) activity, peroxisome proliferator-activated receptor-alpha (PPAR-alpha) ligand activity, fatty acid oxidation, and glucose uptake. ADIPOR2 is also known as progestin and adipoQ receptor family member II (PAQR2), and ACDCR2.

Antibodies for Adiponectin Receptor Detection

Anti-adiponectin receptor antibodies are affinity-purified IgG antibodies that recognize human adiponectin receptor protein variants. These antibodies were raised in rabbit using a synthetic peptide and can be used for Western blot (WB) detection.

  At-A-Glance   Documents

Features

Antigen
Cat. #
Application
Species
(Clone) and Source
Cross‑Reactivity
ADIPOR118993A, BWBHuman

(n/a)
Rabbit IgG

Cross‑reacts with mouse ADIPOR1

Does not cross-react with ADIPOR2
ADIPOR218995A, BWBHuman(n/a)
Rabbit IgG
Cross-reacts with mouse ADIPOR2

Does not cross-react with ADIPOR1

Additional Information

Please see a product's User Manual and Data Sheet for information about storage conditions, product components, and technical specifications. Please see the User Manual to determine kit components. User Manuals and Data Sheets are located under the Documents tab.


 
 
Products
Cat. # Product Contents Size Price Units Select
18995A Anti-Human Adiponectin Receptor 2 Rabbit IgG Affinity Purify 10 ug $113.00
18995B Anti-Human Adiponectin Receptor 2 Rabbit IgG Affinity Purify 100 ug $499.00
18993A Anti-Human Adiponectin Receptor 1 Rabbit IgG Affinity Purify 10 ug $113.00
18993B Anti-Human Adiponectin Receptor 1 Rabbit IgG Affinity Purify 100 ug $499.00
 

 

 
 

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