Monocyte chemoattractant protein-1 (MCP-1) is a 76-amino acid cytokine that belongs to the CC chemokine subfamily. MCP-1 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection. MCP-1 is implicated in several types of chronic inflammatory diseases, such as psoriasis, rheumatoid arthritis, nephritis, and atherosclerosis.
Alternate names for MCP-1 include macrophage/monocyte chemotactic and activating factor (MCAF), chemokine (C-C motif) ligand 2 (CCL2), small inducible cytokine A2, SCYA2, HC11, GDCF-2, SMC-CF, monocyte secretory protein JE, and monocyte chemotactic protein.
ELISAs for MCP-1 Detection
The Rat MCP-1 Assay Kit is a solid-phase sandwich ELISA using two antibodies that are highly specific to recombinant and native rat MCP-1 protein; one is precoated on the ELISA plate and the other is HRP-conjugated. This kit can be used to measure soluble rat MCP-1 protein in serum, urine, or cell culture supernatants.
Antibodies for MCP-1 Detection
The MCP-1 antibody products are affinity-purified IgG antibodies that recognize rat MCP-1 protein. The antibodies were raised in mouse (Cat. #10121A/B) or rabbit (Cat. #18371A/B) using recombinant protein (Cat. #10121A/B) or synthetic peptide (Cat. #18371A/B); these antibodies can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of rat MCP-1 protein.