Suppressor of cytokine signaling 1 (SOCS-1) protein, encoded by the SOCS1 gene, is a member of the STAT-induced STAT inhibitor (SSI) family. SOCS-1 protein can bind to, and inhibit the activity of, kinases that are involved in the JAK/STAT signaling pathway. SOCS1 gene expression is induced by IL2, IL3, erythropoietin, GM-CSF, and interferon (IFN) gamma. In addition to JAK2, SOCS-1 interacts with growth hormone receptor, CD117, colony stimulating factor 1 (CSF1) receptor, and tyrosine-protein kinase Tec. Knockout studies in mice suggested a role for SOCS-1 as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. SOCS-1 is also known as STAT-induced STAT inhibitor 1 (SSI-1), JAK binding protein (JAB), cytokine-inducible SH2 protein 1 (CIS1), CISH-1, and Tec-interacting protein 3 (TIP-3).
This product is an affinity-purified IgG antibody that recognizes human SOCS-1. The antibody was raised in mouse using a synthetic peptide. It can be used for Western blot (WB) detection of human SOCS-1 protein.