Suppressor of cytokine signaling 3 (SOCS-3) protein, encoded by the SOCS3 gene, is a member of the STAT-induced STAT inhibitor (SSI) family. It is also known as cytokine-inducible SH2 protein 3 (CIS3). SOCS-3 is a cytokine-inducible downregulator of cytokine signaling. SOCS3 gene expression can be induced by cytokines such as IL6, IL10, and interferon-gamma. SOCS-3 protein can bind to, and inhibit the activity of, kinases that are involved in the JAK/STAT signaling pathway. Specifically, SOCS-3 is known to inhibit JAK2, as well as tyrosine kinase receptors such as gp130, LIF, erythropoietin, insulin, IL12, GCSF, and leptin receptors. SOCS-3 has been implicated in the negative regulation of fetal liver hematopoiesis and placental development.
Alternate names for SOCS-3 include cytokine-inducible SH2 protein 3 (CIS3), CIS-3, SOCS3, SSI3, SSI-3, ATOD4, and Cish3.
Antibodies for CIS3 SOCS-3 Detection
Anti-human CIS3/SOCS-3 antibody products are affinity-purified IgG antibodies that can be used for Western blot (WB) detection or immunohistochemical (IHC) detection (Cat. # 18391A, B only) of human SOCS-3 protein.