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Cell Biology & Epigenetics


Products >  Cell_Biology_and_Epigenetics >  Cytokines >  CIS3_SOCS-3

CIS3 SOCS-3 Detection

Suppressor of cytokine signaling 3 (SOCS-3) protein, encoded by the SOCS3 gene, is a member of the STAT-induced STAT inhibitor (SSI) family. It is also known as cytokine-inducible SH2 protein 3 (CIS3). SOCS-3 is a cytokine-inducible downregulator of cytokine signaling. SOCS3 gene expression can be induced by cytokines such as IL6, IL10, and interferon-gamma. SOCS-3 protein can bind to, and inhibit the activity of, kinases that are involved in the JAK/STAT signaling pathway. Specifically, SOCS-3 is known to inhibit JAK2, as well as tyrosine kinase receptors such as gp130, LIF, erythropoietin, insulin, IL12, GCSF, and leptin receptors. SOCS-3 has been implicated in the negative regulation of fetal liver hematopoiesis and placental development.

Alternate names for SOCS-3 include cytokine-inducible SH2 protein 3 (CIS3), CIS-3, SOCS3, SSI3, SSI-3, ATOD4, and Cish3.

Antibodies for CIS3 SOCS-3 Detection

Anti-human CIS3/SOCS-3 antibody products are affinity-purified IgG antibodies that can be used for Western blot (WB) detection or immunohistochemical (IHC) detection (Cat. # 18391A, B only) of human SOCS-3 protein. 

  At-A-Glance   Documents   Images & Data

Features

Antigen
Cat. #
Application
Species
(Clone) and Source
Cross‑Reactivity
SOCS-3 (C‑terminus)18391A, BIHC
WB
Human(C204)
Rabbit IgG
Cross-reacts with mouse SOCS-3
SOCS-3 (N‑terminus)18395A, BWBHuman(C005)
Rabbit IgG
Cross-reacts with mouse SOCS-3
SOCS-3 (C‑terminus)10141A, BWBHuman(19A5)
Mouse IgG MoAb
n/a

 

Additional Information

Please see a product's User Manual and Data Sheet for information about storage conditions, product components, and technical specifications. Please see the User Manual to determine kit components. User Manuals and Data Sheets are located under the Documents tab.


 
 
Products
Cat. # Product Contents Size Price Units Select
18391A Anti-Human CIS3/SOCS-3 (C204) Rabbit IgG Affinity Purify 10 ug $113.00
18391B Anti-Human CIS3/SOCS-3 (C204) Rabbit IgG Affinity Purify 100 ug $499.00
18395A Anti-Human CIS3/SOCS-3 (C005) Rabbit IgG Affinity Purify 10 ug $113.00
18395B Anti-Human CIS3/SOCS-3 (C005) Rabbit IgG Affinity Purify 100 ug $499.00
10141A Anti-Human CIS3/SOCS-3 (19A5) Mouse IgG MoAb 20 ug $113.00
10141B Anti-Human CIS3/SOCS-3 (19A5) Mouse IgG MoAb 200 ug $499.00
 

 

 
 

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