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Cell Biology & Epigenetics


Products >  Cell_Biology_and_Epigenetics >  Cell_Biology_Kits >  Proteasome_Monitoring

Proteasome Activity Assay

ZsProSensor-1 is a proteasome-sensitive fluorescent reporter. It is a fusion of a bright green fluorescent protein (Exmax = 496 nm, Emmax = 506 nm) with a degradation domain* which targets the protein for rapid degradation by the proteasome. The cells emit green fluorescence when there is a drop in proteasome activity:

  • Green fluorescence accumulates – the proteasome is inhibited
  • No accumulation of green fluorescence – the proteasome is functioning normally in the cell
The Proteasome Sensor Vector uses the CMV immediate early promoter to drive high levels of ZsProSensor-1 expression.

  At-A-Glance   Documents   Images & Data   Resources

Features

  • Easy fluorescent monitor of proteasome activity
  • Compatible with individual cells or whole populations in real time
  • Easy, non-invasive detection
  • Simple and cost effective assay
  • High-throughput compatible

Applications

  • Drug screens
  • Cancer studies
  • Image based HTS/HCS
  • Real-time proteasome studies

Additional Information

Please see the product's Certificate of Analysis for information about storage conditions, product components, and technical specifications. Please see the Kit Components List to determine kit components. Certificates of Analysis and Kit Components Lists are located under the Documents tab.


 
Products
Cat. # Product Size Price License Units Select
632425 Proteasome Sensor Vector 20 ug $574.00 License Statements *
 
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.

 

 

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