c-Kit is a tyrosine kinase that exists both as a transmembrane protein and a soluble protein. It is the receptor for stem cell factor (SCF), and is also known as v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, stem cell factor receptor (SCFR), piebald trait protein (PBT), and CD117. Functional SCF and c-Kit are critical to the development and survival of hematopoietic stem cells. Interaction of SCF with c-Kit results in increased autophosphorylation activity. Multiple transcripts encoding different isoforms of c-Kit have been reported. High levels of c-Kit expression are found in some types of cancer cells, including gastrointestinal stromal tumors (GIST) and melanoma.
These products are affinity-purified IgG antibodies that recognize human c-Kit protein. The antibodies were raised in mouse or rabbit using a recombinant protein (Cat.# 10349A, 10349B, 10349F) or synthetic peptides (18101A, 18101B, 18105B) and can be used for Western blot (WB) detection (Cat.# 10349A, 10349B, 10349F, 18101A, 18101B), immunohistochemical (IHC) detection (Cat.# 18101A, 18101B, 18105B), immunoprecipitation (IP), or flow cytometry (FC) (10349A, 10349B, 10349F) of human c-Kit protein.