Tenascin-C is a multifunctional extracellular matrix glycoprotein that contains multiple subunits with molecular weights of 210–400 kDa. These subunits include several repeated motifs with similarity to epidermal growth factor (EGF), fibronectin type III (FNIII), and the globular domain of the beta and gamma chains of fibrinogen. Tenascin-C is a ligand that binds to several integrin receptors. During embryonic development, tenascin-C is involved in guidance of migrating neurons and axons, synaptic plasticity, and neuronal regeneration; it is also involved in the development of tendons, bone, and cartilage. Studies in adults have suggested that tenascin-C is upregulated during oncogenesis, arthritis, and liver and lung fibrosis.
Alternate names for tenascin-C include cytotactin, hexabrachion, myotendinous antigen, neuronectin, glioma-associated-extracellular matrix antigen, HXB, TN, TN-C, J1, MGC167029, and GMEM.
ELISAs for Tenascin-C Detection
The tenascin-C ELISA kits are solid-phase sandwich ELISAs that use two highly specific antibodies to non-spliced high-molecular-weight variants of tenascin-C protein; one antibody is precoated onto the ELISA plate and the other is HRP-conjugated. These products can be used to measure soluble human (Cat. # 27751A) or human/mouse/rat (Cat. # 27767A) tenascin-C "large" proteins in serum, plasma, or cell culture supernatants.
Antibodies for Tenascin-C Detection
The anti-human tenascin-C antibody products are affinity-purified IgG antibodies that recognize human tenascin-C protein. The antibodies were raised in mouse using human tenascin-C recombinant protein and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human tenascin-C protein.