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Cell Biology & Epigenetics

Products >  Cell_Biology_and_Epigenetics >  Cancer_and_Inflammation >  Tenascin-C

Tenascin-C Detection

Tenascin-C is a multifunctional extracellular matrix glycoprotein that contains multiple subunits with molecular weights of 210–400 kDa. These subunits include several repeated motifs with similarity to epidermal growth factor (EGF), fibronectin type III (FNIII), and the globular domain of the beta and gamma chains of fibrinogen. Tenascin-C is a ligand that binds to several integrin receptors. During embryonic development, tenascin-C is involved in guidance of migrating neurons and axons, synaptic plasticity, and neuronal regeneration; it is also involved in the development of tendons, bone, and cartilage. Studies in adults have suggested that tenascin-C is upregulated during oncogenesis, arthritis, and liver and lung fibrosis.

Alternate names for tenascin-C include cytotactin, hexabrachion, myotendinous antigen, neuronectin, glioma-associated-extracellular matrix antigen, HXB, TN, TN-C, J1, MGC167029, and GMEM.

ELISAs for Tenascin-C Detection

The tenascin-C ELISA kits are solid-phase sandwich ELISAs that use two highly specific antibodies to non-spliced high-molecular-weight variants of tenascin-C protein; one antibody is precoated onto the ELISA plate and the other is HRP-conjugated. These products can be used to measure soluble human (Cat. # 27751A) or human/mouse/rat (Cat. # 27767A) tenascin-C "large" proteins in serum, plasma, or cell culture supernatants.

Antibodies for Tenascin-C Detection

The anti-human tenascin-C antibody products are affinity-purified IgG antibodies that recognize human tenascin-C protein. The antibodies were raised in mouse using human tenascin-C recombinant protein and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human tenascin-C protein.

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Cat. #
(Clone) and Source
Tenascin‑C (FNIII‑C) “large” nonspliced variants27751AELISAHumanCapture:
Mouse IgG MoAb

Detect: HRP (4F10TT)
Mouse IgG MoAb
Tenascin‑C (FNIII‑B) “large” nonspliced variants27767AELISAHuman
Mouse IgG MoAb

Detect: HRP (4F10TT)
Mouse IgG MoAb
Tenascin-C (domain B, FNIII repeats)10335A, BIHC
Mouse IgG MoAb
Cross‑reacts with mouse and rat tenascin‑C
Tenascin-C (EGF-like domain)10337A, BIHC
Mouse IgG MoAb
Cross-reacts with mouse, rat, chicken, and rabbit tenascin‑C

Additional Information

Please see a product's User Manual and Data Sheet for information about storage conditions, product components, and technical specifications. Please see the User Manual to determine kit components. User Manuals and Data Sheets are located under the Documents tab.

Cat. # Product Contents Size Price Units Select
10335A Anti-Human Tenascin-C (Domain B) (4C8MS) Mouse IgG MoAb 10 ug $113.00
10335B Anti-Human Tenascin-C (Domain B) (4C8MS) Mouse IgG MoAb 100 ug $499.00
10337A Anti-Human Tenascin-C (EGF Like Domain) (4F10TT) Mouse IgG MoAb 10 ug $113.00
10337B Anti-Human Tenascin-C (EGF Like Domain) (4F10TT) Mouse IgG MoAb 100 ug $499.00
27767A Tenascin-C Large (FN Ⅲ-B) Assay Kit - IBL 96-Well $637.00
27751A Human Tenascin-C Large (FN Ⅲ-C) Assay Kit 96-Well $637.00



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