Kinase insert domain receptor (KDR) is one of two main receptors for vascular endothelial growth factor (VEGF). KDR is a type III receptor tyrosine kinase that is the main mediator of VEGF-induced proliferation, survival, migration, and differentiation in endothelial cells. KDR is also known as fetal liver kinase 1 (Flk1), protein-tyrosine kinase receptor flk-1, vascular endothelial growth factor receptor 2 (VEGFR2), CD309, and tyrosine kinase growth factor receptor. Binding of VEGFA, VEGFC, or VEGFD to KDR initiates several signaling cascades, including pathways that involve protein kinase C (PKC), mitogen-activated protein (MAP) kinases, and AKT1 kinase. Mutations in the KDR gene are associated with infantile capillary hemangiomas.
These products are affinity-purified IgG antibodies that recognize human KDR protein. The antibodies were raised in rabbit or mouse using recombinant KDR protein or a synthetic peptide, and can be used for Western blot (WB) detection, immunoprecipitation (IP), neutralization assay (NT), or flow cytometry (FCM) of human KDR protein.