Human HB-EGF Assay Kit
Heparin-binding EGF-like growth factor (HB-EGF) is a glycoprotein member of the EGF family and is a ligand for the ErbB family of tyrosine kinase receptors. HB-EGF is expressed in epidermal cells, cardiac myocytes, vascular endothelial cells, smooth myocytes, and macrophages. It is secreted into the blood and is involved in cell proliferation, differentiation, and inflammatory responses. Recently, it has been proposed that over-expression of HB-EGF plays a vital role in cancer invasion and metastasis, making HB-EGF an attractive drug target.
HB-EGF exists in 3 forms: a membrane-anchored form (proHB-EGF); soluble HB-EGF (sHB-EGF), which is the N-terminal fragment of proHB-EGF that has been separated by proteolytic cleavage at the cell surface; and the C terminal fragment (HB-EGF-CTF), which remains anchored to the cell membrane after cleavage. This solid phase sandwich ELISA kit uses 2 kinds of highly specific antibodies to quantify human HB-EGF in serum, EDTA plasma, urine, cerebrospinal fluid (CSF), and cell culture supernatants.
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