Fatty acid synthase (FAS) is a multifunctional protein, whose primary role is the NADPH-mediated synthesis of palmitate from acetyl-CoA and malonyl-CoA, into long-chain saturated fatty acids. The protein consists of two identical, multifunctional 272 kDa polypeptides. FAS is expressed at high levels in liver, brain, breast, and lung. Studies have reported the in-frame fusion of FAS with estrogen receptor alpha in some cancer cell lines, and FAS expression is upregulated in breast cancer. FAS is also known as OA-519, SDR27X1, and short chain dehydrogenase/reductase family 27X, member 1.
These products are affinity-purified IgG antibodies that recognizes human FAS protein. The antibodies were raised in mouse (Cat.# 10038) or rabbit (Cat.# 18341) using synthetic peptides, and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human FAS protein.