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Cell Biology & Epigenetics

Products >  Cell_Biology_and_Epigenetics >  Cancer_and_Inflammation >  C-Met_Beta

c-Met Detection

The MET proto-oncogene encodes a protein known as c-Met. c-Met, also known as hepatocyte growth factor receptor (HGFR), RCCP2, scatter factor (SF) receptor, and AUTS9, is a heterodimeric protein composed of one alpha and one beta subunit. The highly glycosylated alpha subunit contains the extracellular domain of c-Met, while the beta subunit contains the protein's transmembrane domain. c-Met possesses tyrosine kinase activity and is expressed mainly in epithelial cells. The protein is involved in the activation of several oncogenic pathways as well as in tumor metastasis and angiogenesis.

ELISAs for c-Met Detection

The c-Met ELISA is a solid-phase sandwich ELISA that uses two antibodies that are highly specific to human c-Met; one is a mouse monoclonal antibody that is precoated onto the c-Met ELISA plate and the other is an anti-human mouse antibody that is HRP-conjugated. The c-Met (HGFR) assay can be used to measure soluble human c-Met protein in serum, EDTA plasma, or cell culture supernatants.

Antibodies for c-Met Detection

These products are affinity-purified IgG antibodies that recognize human c-Met (HGFR) protein. The antibodies were raised in rabbit using synthetic peptides and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human c-Met or phosphorylated c-Met (Tyr1235).

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Cat. #
(Clone) and Source
Mouse IgG MoAb

Detect: HRP (n/a)
Mouse IgG MoAb
≤0.1% cross‑reactivity with human HGF, HGFA, HAI-1, and HAI-2
c-Met beta18321A, BIHC
Rabbit IgG
c-Met (phosphorylated Tyr1235 portion)28083A, BIHC
Human(Y1235 Phosphorylated)
Rabbit IgG
Cross-reacts with phosphorylated Tyr1236 portion of rat c-Met

Additional Information

Please see a product's User Manual and Data Sheet for information about storage conditions, product components, and technical specifications. Please see the User Manual to determine kit components. User Manuals and Data Sheets are located under the Documents tab.

Cat. # Product Contents Size Price Units Select
27407A Human c-Met Assay Kit - MCM 96-Well $2,042.00
18321A Anti-Human c-Met beta Rabbit IgG Affinity Purify 10 ug $125.00
18321B Anti-Human c-Met beta Rabbit IgG Affinity Purify 100 ug $545.00
28083A Anti-c-Met (Y1235 Phosphorylated) Rabbit IgG Affinity Purify 5 ug $126.00
28083B Anti-c-Met (Y1235 Phosphorylated) Rabbit IgG Affinity Purify 50 ug $574.00



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