Synaptotagmins are a family of proteins originally thought to function as calcium sensors in the regulation of neurotransmitter release and hormone secretion. Synaptotagmin IV binds calcium through its two C-terminal C2 domains (C2A and C2B). It may be involved in calcium-dependent exocytosis of secretory vesicles, through binding of calcium and phospholipids to the C2 domain. It may also serve as a calcium sensor in the process of vesicular trafficking and exocytosis. Synaptotagmin IV is expressed in brain, at high levels in hippocampus, with substantial levels also detected in amygdala and thalamus. Synaptotagmin IV is also known as synaptotagmin-4, SYT4, HsT1192, KIAA1342, and SytIV.
This product is an affinity-purified IgG antibody that recognizes human, mouse, and rat synaptotagmin IV protein. The antibody was raised in rabbit using recombinant synaptotagmin IV protein and can be used for Western blot (WB) detection, immunocytochemical (ICC) detection, or immunoprecipitation (IP) of human, mouse, and rat synaptotagmin IV protein.