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Cell Biology & Epigenetics


Products >  Cell_Biology_and_Epigenetics >  Brain_and_CNS >  Septin

Septin Detection

The septin family of nucleotide-binding proteins was originally identified in yeast as cell division regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse; they are thought to regulate cytoskeletal organization.

Septin 4 is encoded by the SEPT4 gene in humans and is expressed at high levels in the brain and heart. It is a filament-forming GTPase that is localized to the cytoskeleton. Septin 4 may also play a role in cytokinesis. Septin 4 exists as several isoforms, one of which is found in mitochondria and is implicated in apoptosis and cancer. Alternate names for septin 4 include apoptosis-related protein in the TGF-beta signaling pathway (ARTS), bradeion beta, brain protein H5, H5, MART, SEP4, cell division control-related protein 2, cerebral protein 7, CE5B3, CE5B3 beta, Peanut-like protein 2 (PNUTL2), hucep-7, hCDCREL-2, and septin-M.

Septin 7 is highly similar to yeast CDC10, Drosophila Diff 6, and mouse H5 protein. Each of these proteins contains a GTP-binding motif. It functions in gliomagenesis and in the suppression of glioma cell growth. It is required for the association of centromere-associated protein E with the kinetochore during mitosis. Alternative splicing results in multiple isoforms of septin 7. Abnormal expression patterns of some septins have been reported in human cancers and neurodegenerative diseases. Alternate names include cell division cycle 10 (CDC10) homolog (S. cerevisiae), CDC3, CDC10, SEPT7A, and NBLA02942.

Antibodies for Septin Detection

The anti-human septin antibody products are affinity-purified IgG antibodies that recognize human septin 4 and septin 7 protein. The antibodies were raised in rabbit using synthetic peptides and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human septin 4 or septin 7.

  At-A-Glance   Documents   Images & Data

Features

Antigen
Cat. #
Application
Species
(Clone) and Source
Cross‑Reactivity
Septin 4 (N‑terminus)18987A, BIHC
WB
Human(n/a)
Rabbit IgG
Cross-reacts with mouse and rat septin 4
Septin 4 (C‑terminus)18989A, BIHC
WB
Human(n/a)
Rabbit IgG
Cross-reacts with mouse and rat septin 4
Septin 7 (C‑terminus)18991A, BIHC
WB
IP
Human(n/a)
Rabbit IgG
Cross-reacts with mouse and rat septin 7

 

Additional Information

Please see a product's User Manual and Data Sheet for information about storage conditions, product components, and technical specifications. Please see the User Manual to determine kit components. User Manuals and Data Sheets are located under the Documents tab.


 
 
Products
Cat. # Product Contents Size Price Units Select
18987A Anti-Human Septin 4 (N) Rabbit IgG Affinity Purify 10 ug $113.00
18987B Anti-Human Septin 4 (N) Rabbit IgG Affinity Purify 100 ug $499.00
18989A Anti-Human Septin 4 (C) Rabbit IgG Affinity Purify 10 ug $113.00
18989B Anti-Human Septin 4 (C) Rabbit IgG Affinity Purify 100 ug $499.00
18991A Anti-Human Septin 7 (C) Rabbit IgG Affinity Purify 10 ug $113.00
18991B Anti-Human Septin 7 (C) Rabbit IgG Affinity Purify 100 ug $499.00
 

 

 
 

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