The term S-100 protein is used to describe a family of low-molecular-weight proteins, found in vertebrates, that are 100% soluble in ammonium sulfate at neutral pH. Over 20 types of S-100 proteins are known at present. S-100 proteins all have calcium-binding sites and a helix-loop-helix (HLH) domain. They are usually found in Schwann cells, melanocytes, and glial cells. S-100 proteins are involved in a wide range of functions, from regulation of calcium homeostasis to the inflammatory response. Some S-100 proteins are markers for certain types of cancer, as well as inflammatory diseases.
These products are affinity-purified IgG antibodies that recognize bovine and human S-100 proteins. The antibodies were raised in mouse or rabbit using bovine brain S-100 proteins and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of S-100 proteins.