Hypoxia upregulated protein 1, encoded by the HYOU1 gene, belongs to the heat shock protein 70 family. It is also known as 150 kDa oxygen-regulated protein (ORP150), 170 kDa glucose-regulated protein (GRP170), glucose-regulated protein 170, and HSP12A. The HYOU1 gene is transcribed into three mRNAs, due to the use of alternative transcription sites. A segment at the 5' end of exon 1A is involved in stress-dependent induction and results in the accumulation of ORP150 in the endoplasmic reticulum under low oxygen conditions. Suppression of the HYOU1 gene is associated with accelerated apoptosis, while its upregulation is associated with tumor development and invasiveness.
This product is an affinity-purified IgG antibody that recognizes human ORP150 protein. The antibody was raised in mouse using recombinant ORP150 and can be used for Western blot (WB) detection, immunohistochemical (IHC) detection, or immunoprecipitation (IP) of human ORP150 protein.