Leucine-rich alpha-2-glycoprotein 1 (LRG1) is a member of the leucine-rich repeat (LRR) family of proteins that are involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 was first identified as a trace component in human serum and was characterized as a marker for early neutrophilic granulocyte differentiation. LRG1 contains a 24-amino acid consensus sequence, the leucine-rich repeat, which is found in other LRG-family proteins. LRG is expressed in primary human neutrophils, and its expression is upregulated during neutrophilic granulocyte differentiation of human and murine cell lines. High levels of LRG1 have been reported in the cerebrospinal fluid of patients with idiopathic normal pressure hydrocephalus (iNPH), and LRG1 measurement can be useful to distinguish iNPH from early-stage Alzheimer's disease symptoms.
Alternate names for LRG1 include LRG, HMFT1766, 1300008B03Rik, and 2310031E04Rik.
ELISAs for LRG Detection
These kits are solid-phase sandwich ELISAs using two antibodies that are highly specific to mouse (Cat. # 27785A), human (Cat. # 27769A), or rat (Cat. # 27770A) LRG1 protein; the capture antibody is precoated on the ELISA plate and the detection antibody is HRP-conjugated. These kits can be used to measure soluble LRG1 protein in serum, EDTA plasma, urine, or cerebrospinal fluid.
Antibodies for LRG Detection
These products are affinity-purified IgG antibodies that recognize human or rat LRG1 protein. The antibodies were raised in rabbit using synthetic peptides, and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human or rat LRG1 protein.