The septin gene family of nucleotide binding proteins were originally identified in yeast as cell division regulatory proteins. Septin 5--also known as CDCrel-1, HCDCREL-1, peanut-like 1 (Pnutl1), platelet glycoprotein Ib beta chain--is encoded by the SEPT5 gene in humans. A translocation involving the MLL gene and the SEPT5 gene has been reported in acute myeloid leukemia. Alternative splicing results in several septin 5 variants. Septin 5 is known to interact with septin 8 and Parkin 8; mutations in the Parkin 8 gene are implicated in dopaminergic cell death and consequent development of an autosomal recessive form of Parkinson's disease.
This product is an affinity-purified IgG antibody that recognizes human CDCrel-1 protein. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection, immunohistochemical (IHC) detection, or immunoprecipitation (IP) of human CDCrel-1 protein.