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Cell Biology & Epigenetics


Products >  Cell_Biology_and_Epigenetics >  Brain_and_CNS >  Alpha-Synuclein

Alpha-Synuclein Detection

Synuclein family members (alpha-, beta-, and gamma-synuclein) are expressed at high levels in adult brain tissue and in some tumors. Alpha-synuclein is encoded by the SNCA gene in humans and is mainly expressed in the cerebral neocortex, hippocampus, nigra, thalamus, and metencephalon, with the majority of the protein localizing to the presynaptic terminal and nucleus of neuron cells. The exact function of alpha-synuclein is unknown, but it may be involved in presynaptic signaling and membrane trafficking. Alpha-synuclein can aggregate to form insoluble fibrils in pathological conditions, such as Parkinson's disease, Lewy body dementia (associated with both Alzheimer's and Parkinson's disease), and multiple system atrophy. Mutations in the SNCA gene have been associated with the pathogenesis of Parkinson disease.

Alternate names: non A-beta component of AD amyloid, non-A4 component of amyloid precursor, NACP, PD1, PARK1, and PARK4.

ELISAs for Alpha-Synuclein Detection

The human alpha-synuclein assay kit (Cat. # 27740A) is a solid-phase sandwich ELISA using two kinds of highly specific antibodies. This assay kit is capable of quantitative determination of human alpha-synuclein in serum, EDTA plasma, cerebrospinal fluid (CSF), and cell culture supernatant.

Antibodies for Alpha-Synuclein Detection

Anti-human alpha-synuclein antibody (Cat. # 18671A, B) is an affinity-purified IgG antibody that recognizes human alpha-synuclein protein. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human alpha-synuclein protein.

  At-A-Glance   Documents   Images & Data

Features

Antigen
Cat. #
Application
Species
(Clone) and Source
Cross‑Reactivity
Alpha-synuclein27740AELISAHumanCapture:
(3G11)
Mouse IgG MoAb

Detect: HRP (5G12)
Mouse IgG MoAb
n/a
Alpha-synuclein (C‑terminus)18671A, BIHC
WB
Human(S122)
Rabbit IgG
Cross‑reacts with mouse and rat alpha-synuclein

 

Additional Information

Please see a product's User Manual and Data Sheet for information about storage conditions, product components, and technical specifications. Please see the User Manual to determine kit components. User Manuals and Data Sheets are located under the Documents tab.


 
 
Products
Cat. # Product Contents Size Price Units Select
18671A Anti-Human alpha-Synuclein (S122) Rabbit IgG Affinity Purify 10 ug $113.00
18671B Anti-Human alpha-Synuclein (S122) Rabbit IgG Affinity Purify 100 ug $499.00
27740A Human alpha-Synuclein Assay Kit - IBL 96-Well $924.00
 

 

 
 

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