Synuclein family members (alpha-, beta-, and gamma-synuclein) are expressed at high levels in adult brain tissue and in some tumors. Alpha-synuclein is encoded by the SNCA gene in humans and is mainly expressed in the cerebral neocortex, hippocampus, nigra, thalamus, and metencephalon, with the majority of the protein localizing to the presynaptic terminal and nucleus of neuron cells. The exact function of alpha-synuclein is unknown, but it may be involved in presynaptic signaling and membrane trafficking. Alpha-synuclein can aggregate to form insoluble fibrils in pathological conditions, such as Parkinson's disease, Lewy body dementia (associated with both Alzheimer's and Parkinson's disease), and multiple system atrophy. Mutations in the SNCA gene have been associated with the pathogenesis of Parkinson disease.
Alternate names: non A-beta component of AD amyloid, non-A4 component of amyloid precursor, NACP, PD1, PARK1, and PARK4.
ELISAs for Alpha-Synuclein Detection
The human alpha-synuclein assay kit (Cat. # 27740A) is a solid-phase sandwich ELISA using two kinds of highly specific antibodies. This assay kit is capable of quantitative determination of human alpha-synuclein in serum, EDTA plasma, cerebrospinal fluid (CSF), and cell culture supernatant.
Antibodies for Alpha-Synuclein Detection
Anti-human alpha-synuclein antibody (Cat. # 18671A, B) is an affinity-purified IgG antibody that recognizes human alpha-synuclein protein. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human alpha-synuclein protein.