The Human Tau Antibody products are affinity-purified IgG antibodies that recognize human tau protein isoforms. The anti-human tau antibodies are raised in mouse or rabbit using synthetic peptides or brain tissue isolates and are applicable for Western blot (WB) or immunohistochemistry (IHC) detection of human tau protein isoforms.
The human microtubule-associated protein tau (MAPT) gene transcript undergoes a complex series of alternative splicing events that result in several differentially expressed mRNA species. The protein isoforms translated from these mRNAs are distinguished by the number of binding domains located at their carboxy termini and can range in length from 352 to 441 amino acids.
Tau proteins promote the assembly and stability of microtubules in neuronal cells, and primarily in the distal portions of axons. Mutations in the MAPT gene are associated with a range of neurodegenerative diseases including Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. Hyperphosphorylation of tau proteins leads to the assembly of tangled filaments that are implicated in the pathogenesis of Alzheimer's disease.
Tau is also known as microtubule-associated protein tau (MAPT), neurofibrillary tangle protein, paired helical filament-tau (PHF-tau), G protein beta1/gamma2 subunit-interacting factor 1, MTBT1, MAPTL, DDPAC, MSTD, FTDP-17, MTBT2, PPND, FLJ31424 and MGC138549.