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Cell Biology & Epigenetics

Products >  Cell_Biology_and_Epigenetics >  Alzheimers_Disease >  BACE1

Beta-secretase (BACE1) Detection

The accumulation of amyloid-beta protein in the cerebral cortex in Alzheimer's disease (AD) is one outcome of proteolytic cleavage of amyloid precursor protein (APP). Aberrant cleavage can occur due to the more than 50 mutations documented in the APP gene that are associated with early-onset Alzheimer's disease. Cleavage by beta- and gamma-secretase (in the amyloidogenic pathway) leads to production of insoluble amyloid-beta and soluble APP-beta proteins. The major beta-secretase enzyme is beta-site APP cleaving enzyme 1 (BACE1), a transmembrane protein that contains two aspartate residues in its active site. Elevated levels of BACE1 have been correlated with late-onset sporadic AD.

Alternative names: aspartyl protease 2 (ASP2), beta-secretase 1, HSPC104, KIAA1149, membrane-associated aspartic protease 2, and memapsin-2.

ELISAs for BACE1 Detection

The BASE1 ELISA Kit is a solid phase sandwich ELISA with two highly specific antibodies; one is precoated on the ELISA plate and the other is HRP-conjugated. This assay can be used to measure human, mouse, or rat BACE1 protein in brain tissue extracts or cultured cell lysates.

Antibodies for BACE1 Detection

The Human BACE1 Antibody products are affinity-purified IgG antibodies that recognize human BACE1 protein. The BACE1 antibodies are raised in rabbit using synthetic peptides and can be applied to Western blot (WB) and immunohistochemical (IHC) detection as well as immunoprecipitation (IP) of human BACE1 protein.

  At-A-Glance   Documents   Images & Data


Cat. #
(Clone) and Source
BACE127752AELISAHuman Mouse RatCapture:
Rabbit IgG

Detect: HRP (n/a)
Rabbit IgG
Reacts with human, mouse, and rat BACE1 (native or recombinant)
BACE1 (C-terminus)18711A, BWB
Rabbit IgG 
Cross‑reacts with mouse and rat BACE1
BACE128051A, BWB
Rabbit IgG
Cross-reacts with mouse and rat BACE1


Additional Information

Please see a product's User Manual and Data Sheet for information about storage conditions, product components, and technical specifications. Please see the User Manual to determine kit components. User Manuals and Data Sheets are located under the Documents tab.

Cat. # Product Contents Size Price Units Select
18711A Anti-Human BACE1 (C) Rabbit IgG Affinity Purify 10 ug $113.00
18711B Anti-Human BACE1 (C) Rabbit IgG Affinity Purify 100 ug $499.00
28051A Anti-BACE1 (42) Rabbit IgG Affinity Purify 10 ug $113.00
28051B Anti-BACE1 (42) Rabbit IgG Affinity Purify 100 ug $499.00
27752A BACE1 Assay Kit - IBL 96-Well $606.00



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