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Cell Biology & Epigenetics


Products >  Cell_Biology_and_Epigenetics >  Alzheimers_Disease >  ApoE

Apolipoprotein E Detection

Apolipoprotein E (ApoE) is a main component of chylomicrons—lipoprotein particles that contain triglycerides, phospholipids, cholesterol, and proteins. Three isoforms of ApoE are produced by alternative splicing: ApoE2, ApoE3, and ApoE4. The primary role of ApoE is to transport dietary lipoproteins, fat-soluble vitamins, and cholesterol from the intestine into the lymphatic system and then through the blood to tissues. Normal functioning of ApoE is essential to prevent the accumulation of cholesterol and triglycerides in the blood. ApoE expression is highest in the liver, but has also been found in other tissues such as the brain, kidneys, spleen, and nervous system. The ApoE receptor belongs to the highly conserved low density lipoprotein (LDL) receptor gene family; seven mammalian ApoE receptors have been identified. Mutations in the APOE gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III). Recent studies have implicated roles for ApoE in processes that are not directly related to lipid transport, including Alzheimer's disease, immunoregulation, and cognitive function.

Alternative names: Apo-E, AD2, LPG, and LDLCQ5.

Antibodies for Apolipoprotein Detection

These products are affinity-purified IgG antibodies that recognize human ApoE proteins and ApoE4 protein, respectively. The ApoE (A299) antibody (Cat. #18171A, B) was raised in rabbit and the ApoE4 (5B5) antibody (Cat. #10025A, B) was raised in mouse, both using synthetic peptides. Both antibodies can be used for Western blot (WB) and immunohistochemical (IHC) detection.

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Features

Antigen/Peptide
Cat. #
Application
Species
(Clone) and Source
Cross‑Reactivity
ApoE
(C-terminus)
18171A, BWB
IHC
Human(A299)
Rabbit IgG
Reacts with ApoE2, ApoE3, and ApoE4
ApoE410025A, BWB
IHC
Human(5B5)
Mouse IgG 
MoAb
Does not cross‑react with ApoE2 or ApoE3

 

Additional Information

Please see a product's User Manual and Data Sheet for information about storage conditions, product components, and technical specifications. Please see the User Manual to determine kit components. User Manuals and Data Sheets are located under the Documents tab.


 
 
Products
Cat. # Product Contents Size Price Units Select
18171A Anti-Human ApoE (A299) Rabbit IgG Affinity Purify 5 ug $113.00
18171B Anti-Human ApoE (A299) Rabbit IgG Affinity Purify 100 ug $499.00
10025A Anti-Human ApoE4 (5B5) Mouse IgG MoAb 10 ug $113.00
10025B Anti-Human ApoE4 (5B5) Mouse IgG MoAb 200 ug $499.00
 

 

 
 

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