Apolipoprotein E (ApoE) is a main component of chylomicrons—lipoprotein particles that contain triglycerides, phospholipids, cholesterol, and proteins. Three isoforms of ApoE are produced by alternative splicing: ApoE2, ApoE3, and ApoE4. The primary role of ApoE is to transport dietary lipoproteins, fat-soluble vitamins, and cholesterol from the intestine into the lymphatic system and then through the blood to tissues. Normal functioning of ApoE is essential to prevent the accumulation of cholesterol and triglycerides in the blood. ApoE expression is highest in the liver, but has also been found in other tissues such as the brain, kidneys, spleen, and nervous system. The ApoE receptor belongs to the highly conserved low density lipoprotein (LDL) receptor gene family; seven mammalian ApoE receptors have been identified. Mutations in the APOE gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III). Recent studies have implicated roles for ApoE in processes that are not directly related to lipid transport, including Alzheimer's disease, immunoregulation, and cognitive function.
Alternative names: Apo-E, AD2, LPG, and LDLCQ5.
Antibodies for Apolipoprotein Detection
These products are affinity-purified IgG antibodies that recognize human ApoE proteins and ApoE4 protein, respectively. The ApoE (A299) antibody (Cat. #18171A, B) was raised in rabbit and the ApoE4 (5B5) antibody (Cat. #10025A, B) was raised in mouse, both using synthetic peptides. Both antibodies can be used for Western blot (WB) and immunohistochemical (IHC) detection.