Amyloid beta (A4) precursor-like protein 1 (APLP1) is a member of the highly conserved amyloid precursor protein (APP) family. It is also known as amyloid precursor-like protein 1 and amyloid-like protein 1. APLP1 is a membrane-associated glycoprotein that is cleaved by beta-secretase (BACE) and gamma-secretase in a similar fashion to APP itself. The cleavage products are secreted into cerebrospinal fluid like those derived from APP, but they do not accumulate in the cerebral cortex. Three cleavage APLP1-derived Abeta-like peptides (APL1-beta) are known: APL1-beta25, APL1-beta27, and APL1-beta28. These peptides have been suggested as novel biomarkers for Alzheimer's disease.
These kits are solid-phase sandwich ELISAs using two antibodies that are highly specific to human APL1-beta25, APL1-beta27, and APL1-beta28; one is precoated on the ELISA plate and the other is HRP-conjugated. These assay kits can be used to measure soluble human APL1-beta25, APL1-beta27, and APL1-beta28 in cerebrospinal fluid or cell culture supernatants.