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Hitting Back at Hepatitis B

(runtime: 2:07 min)

Hepatitis B not only hijacks cells to make legions of new infectious particles, it also establishes long-term infections and leads to hepatocellular carcinoma. Wu and colleagues examined how expression of the oncogenic Hepatitis B virus X protein (HBx) alters miRNA expression in cultured liver cells. Using the SYBR® PrimeScript RT-PCR kit to measure miRNAs via real-time PCR, they observed down-regulation of miR-16 members involved in cell cycle regulation. Reintroducing miR-16 to HBx-expressing cells suppressed key hallmarks of cancer. That's Good Science!

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