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cDNA Synthesis & Library Construction

Products >  cDNA_Synthesis_and_Library_Construction >  NGS_Automation >  Library_Prep_Automation >  SMARTer_Apollo_NGS_Library_Prep_System

SMARTer Apollo NGS library prep system

Next-generation sequencing applications enable researchers to delve deeper into the human genome. Although NGS applications allow diverse and detailed analysis, NGS library preparation is encumbered by extensive hands-on and labor-intensive workflows. To address this, the SMARTer Apollo system provides a complete, walkaway solution using validated protocols and chemistries that produce consistent libraries for DNA-seq, RNA-seq, and ChIP-seq applications.

The SMARTer Apollo system offers best-in-class performance and flexibility. Manual NGS library prep workflows are labor-intensive and prevent you from conducting other valuable experiments. The SMARTer Apollo system frees you from manual steps by automating the critical portions of the workflow, reducing your hands-on time to just 30 minutes, depending on the sample throughput and script used. The SMARTer Apollo system can also run flexible batch sizes without wasting reagents or time. In addition to both DNA and RNA NGS library prep protocols, this versatile system efficiently performs related protocols for sample preparation and cleanup, such as poly A+ RNA enrichment, rRNA depletion, and PCR cleanup.

Manual NGS library preparation is not only time-consuming, but it is also subject to human error, affecting the quality of your data. Consistency is key when processing multiple samples; the SMARTer Apollo system, combined with SMARTer PrepX chemistries and scripts, allows you to create consistent target libraries without the variability caused by manual pipetting. Protocols using SMARTer PrepX kits on the SMARTer Apollo system have been validated as a seamless solution for consistent sample preparation, cleanup, and NGS library prep. An adapted protocol for automating SMART-Seq v4 ultra-low-input RNA-seq library prep applies our industry-leading chemistry to process up to 96 samples in a single working day. These protocols employ in-tip bead separation for efficient capture of libraries in a highly reproducible manner.

  At-A-Glance   Documents   Images & Data


  • Convenient library prep—reduce hands-on time with SMARTer PrepX or SMART-Seq v4 chemistries and walkaway automation
  • Flexible throughput—run any batch size, up to 96 samples per run
  • Unique in-tip bead separation—watch a video on how the SMARTer Apollo system increases sample recovery and reproducibility
  • Reliable results—increase reproducibility and minimize contamination with a completely enclosed, automated system

Technical Specifications

System Features

  • Eight deck positions enable flexible configuration of consumables and reagents
  • Two Peltier blocks hold samples at high or low temperatures
  • Automated magnetic bar effectively captures magnetic beads within the tips
  • Integrated touchscreen with helpful graphic user interface makes deck setup easy

System Specifications
  • Maximum number of samples: 96/run
  • Handling volume: 5–200 μl
  • Temperature control: 4–95°C
  • Power requirements: 100–240 VAC, 50/60 Hz, 300 W, 120 V; 1,500 VA uninterruptible power supply required
  • Environmental conditions: 15–30°C ambient; 15–75% relative humidity, noncondensing; <2,000 m above sea level
  • Dimensions*: (W) 800 mm, (H) 700 mm, (D) 675 mm
  • Weight: 97 kg (excludes accessories and disposables)

*The instrument should be placed such that there is a distance of at least 200 mm between any surrounding walls (including the ceiling) and the instrument.


The following table lists our validated reagent kits for the SMARTer Apollo system.

Cat. #SMARTer Apollo reagent kit
640170*SMART-Seq v4 Reagent Kit for the SMARTer Apollo System
640101SMARTer PrepX Complete ILMN DNA Library Kit, 24 Samples
640102SMARTer PrepX Complete ILMN 32i DNA Library Kit, 96 Samples
640096SMARTer PrepX RNA-Seq for Illumina Library Kit, 24 Samples
640097SMARTer PrepX RNA-Seq for Illumina Library Kit, 48 Samples
640098SMARTer PrepX PolyA mRNA Isolation Kit, 96 Samples
640099SMARTer PrepX Small RNA for Illumina Library Kit, 24 Samples
640100SMARTer PrepX Small RNA for Illumina Library Kit, 48 Samples

*Cat. # 640170 provides enough reagent to run 96 samples in batches of up to 32 samples.

Additional Product Information

Please see the product's Certificate of Analysis for information about storage conditions, product components, and technical specifications. Please see the Kit Components List to determine kit components. Certificates of Analysis and Kit Components Lists are located under the Documents tab.


Cat. # Product Contents Size Price Units Select
640078 SMARTer™ Apollo™ Library Prep System Each $95,000.00



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